| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-05 |
| タイトル |
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タイトル |
Molecular dynamics study on clustered DNA damage: AP sites on the same strand |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Terakawa Kazushi
Fujiwara Susumu
Mizuguchi Tomoko
Nakamura Hiroaki
Akamatsu Ken
Shikazono Naoya
Yonetani Yoshiteru
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Although radiation-induced clustered DNA damage can have critical biological consequences, the underlying molecular mechanisms remain unclear. To explore the effect of clustered DNA damage on DNA structure and dynamics, we performed molecular dynamics simulations on damaged DNA with two AP sites on the same strand, that is, a tandem AP cluster. The results showed that the cluster insertion of the two AP sites had a significant impact on the DNA’s local and global structures. Local structural deformations as well as the extrahelical form, AP-base pairs, and irregular base pairs were frequently observed. Unlike a single AP site, the tandem AP cluster revealed that these local structural features occurred simultaneously within a small separation. Moreover, we found that the presence of tandem AP sites induced global bending of DNA. This suggests that the present case with tandem AP sites may have a non-negligible impact on the biological function of damage repair. |
| 書誌情報 |
Biophysical Chemistry
巻 319,
p. 107394,
発行日 2025-04
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| 出版者 |
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出版者 |
Elsevier |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bpc.2025.107394 |
