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Patient CT-based simulation study of secondary-electron-bremsstrahlung imaging for range verification in proton therapy: Comparison with prompt gamma and PET imaging for simplified proton pencil beam and SOBP irradiation scenarios
https://repo.qst.go.jp/records/2001460
https://repo.qst.go.jp/records/20014604bc1cb2f-1469-48e7-bf68-b12f45d50076
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2025-05-08 | |||||||||||||||||
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| タイトル | Patient CT-based simulation study of secondary-electron-bremsstrahlung imaging for range verification in proton therapy: Comparison with prompt gamma and PET imaging for simplified proton pencil beam and SOBP irradiation scenarios | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
矢部 卓也
× 矢部 卓也
× Nitta Munetaka (LMU)
× 山口 充孝
× Pinto Marco (LMU)
× 河地 有木
× Parodi Katia (LMU)
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Objective: Secondary electron bremsstrahlung (SEB) imaging, along with prompt gamma (PG) and positron emission tomography (PET) imaging, has been proposed as an in vivo range verification tool for proton therapy. This study presents the first patient simulation to investigate the feasibility of SEB imaging for range verification in proton therapy, while comparing the characteristics of SEB imaging with those of PG and PET imaging. Approach: A Monte Carlo simulation was performed using patient computed tomography (CT) data for the irradiation of monoenergetic pencil beams and spread-out Bragg peak proton beams. The physical characteristics of SEB imaging were analyzed at different anatomical sites and compared with those of PG and PET imaging. Main results: In all the treatment cases, SEB imaging exhibited higher production rates than PG and PET imaging, particularly in the regions with high CT values along the beam path. Although the SEB signal was more affected by scattering and absorption than the PET or PG signals, sufficient statistical counts for range verification (~3 × 10?3 SEBs/ proton) could potentially be detected outside the patient geometry. For pencil beam cases, the SEB and PET fall-offs were located 4?5 mm proximal to the dose fall-off, while the PG fall-off was located 0?1 mm distal to it. Significance: Results suggest that SEB imaging has the potential to offer a real-time range verification tool (by comparing measured and expected images), particularly for treating shallow-seated tumors using proton pencil-beam scanning delivery. Thus, this study represents a significant step towards the clinical application of range verification based on SEB imaging and promotes future efforts in this direction. |
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| 書誌情報 |
Physics in Medicine & Biology 発行日 2025-05 |
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| 出版者 | IOP Publishing | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1361-6560 | |||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1088/1361-6560/add4b7?? | |||||||||||||||||
