| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-17 |
| タイトル |
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タイトル |
Verification of linear energy transfer optimized carbon-ion radiotherapy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Mizuno Hideyuki
Nakaji Taku
Sung-Hyun Lee
Sakata Dousatsu
Aoki Katsumi
Mizushima Kota
Thuy Linh Tran
Anatoly Rosenfeld
Inaniwa Taku
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective Linear energy transfer (LET) verification was conducted using a silicon-on-insulator (SOI) microdosimeter during the commissioning of LET-optimized carbon-ion radiotherapy. This advanced treatment technique is expected to improve local control rates, especially in hypoxic tumors. Approach An SOI microdosimeter with a cylindrical sensitive volume of 30 μm diameter and 5 μm thickness was used. Simple cubic plans and patient plans using the carbon-ion beams were created by treatment planning system, and the calculated LETd values were compared with the measured LETd values obtained by the SOI microdosimeter. Main results Reasonable agreement between the measured and calculated LETd was seen in the plateau region of depth LETd profile, whereas the measured LETd were below the calculated LETd in the peak region, specifically where LETd exceeds 75 keV/μm. The discrepancy in the peak region may arise from the uncertainties in the calibration process of the SOI microdosimeter. Excluding the peak region, the average ratio and standard deviation between measured and calculated LETd values were 0.996 and 7%, respectively. Significance This verification results in the initiation of clinical trials for LET-optimized carbon-ion radiotherapy at QST Hospital, National Institutes for Quantum Science and Technology. |
| 書誌情報 |
Physics in Medicine and Biology
巻 69,
号 23,
p. NT01,
発行日 2024-11
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| 出版者 |
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出版者 |
IOP Publishing |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1361-6560 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
39509821 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1088/1361-6560/ad8fec |
