| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-09 |
| タイトル |
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タイトル |
Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism. |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Zhilei Zhao
Naohiro Okada
Sho Yagishita
Noriaki Yahata
Nobuhiro Nitta
Sayaka Shibata
Yoshifumi Abe
Susumu Morita
Eureka Kumagai
Kenji F Tanaka
Tetsuya Suhara
Toru Takumi
Kiyoto Kasai
Seiichiro Jinde
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Duplication of chromosome 15q11-13 has been reported to be one of the most frequent cytogenetic copy number variations in autism spectrum disorder (ASD), and a mouse model of paternal 15q11-13 duplication was generated, termed 15q dup mice. While previous studies have replicated some of the behavioral and brain structural phenotypes of ASD separately, the relationship between brain structure and behavior has rarely been examined. In this study, we performed behavioral experiments related to anxiety and social behaviors and magnetic resonance imaging (MRI) using the same set of 15q dup and wild-type mice. 15q dup mice showed increased anxiety and a tendency toward alterations in social behaviors, as reported previously, as well as variability in terms of sociability. MRI analysis revealed that a lower sociability index was correlated with a smaller gray matter volume in the right medial entorhinal cortex. These results may help to understand how variability in behavioral phenotypes of ASD arises even in individuals with the same genetic background and to determine the individual differences in neurodevelopmental trajectory correlated with specific brain structures that underlie these phenotypes. |
| 書誌情報 |
Neuroscience research
巻 209,
p. 42-49,
発行日 2024-12
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1872-8111 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
39097003 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.neures.2024.07.009 |
