| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-30 |
| タイトル |
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タイトル |
Effects of a 5-HT4 receptor antagonist in the caudate nucleus on the performance of macaques in a delayed reward task |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hori Yukiko
Iwaoki Haruhiko
Mimura Koki
Nagai Yuji
Higuchi Makoto
Minamimoto Takafumi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Temporal discounting, in which the recipient of a reward perceives the value of that reward to decrease with delay in its receipt, is associated with impulsivity and psychiatric disorders such as depression. Here, we investigate the role of the serotonin 5-HT4 receptor (5-HT4R) in modulating temporal discounting in the macaque dorsal caudate nucleus (dCDh), the neurons of which have been shown to represent temporally discounted value. We first mapped the 5-HT4R distribution in macaque brains using positron emission tomography (PET) imaging and confirmed dense expression of 5-HT4R in the dCDh. We then examined the effects of a specific 5-HT4R antagonist infused into the dCDh. Blockade of 5-HT4R significantly increased error rates in a goal-directed delayed reward task, indicating an increase in the rate of temporal discounting. This increase was specific to the 5-HT4R blockade because saline controls showed no such effect. The results demonstrate that 5-HT4Rs in the dCDh are involved in reward-evaluation processes, particularly in the context of delay discounting, and suggest that serotonergic transmission via 5-HT4R may be a key component in the neural mechanisms underlying impulsive decisions, potentially contributing to depressive symptoms. |
| 書誌情報 |
Scientific reports
巻 14,
p. 19619,
発行日 2024-08
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| 出版者 |
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出版者 |
Nature Portfolio |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
39179718 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-024-70414-6 |
