| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-07-16 |
| タイトル |
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タイトル |
Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Toshiyuki Hirabayashi
Yuji Nagai
Yuki Hori
Yukiko Hori
Kei Oyama
Koki Mimura
Naohisa Miyakawa
Haruhiko Iwaoki
Ken-Ichi Inoue
Tetsuya Suhara
Masahiko Takada
Makoto Higuchi
Takafumi Minamimoto
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Visual object memory is a fundamental element of various cognitive abilities, and the underlying neural mechanisms have been extensively examined especially in the anterior temporal cortex of primates. However, both macroscopic large-scale functional network in which this region is embedded and microscopic neuron-level dynamics of top-down regulation it receives for object memory remains elusive. Here, we identified the orbitofrontal node as a critical partner of the anterior temporal node for object memory by combining whole-brain functional imaging during rest and a short-term object memory task in male macaques. Focal chemogenetic silencing of the identified orbitofrontal node downregulated both the local orbitofrontal and remote anterior temporal nodes during the task, in association with deteriorated mnemonic, but not perceptual, performance. Furthermore, imaging-guided neuronal recordings in the same monkeys during the same task causally revealed that orbitofrontal top-down modulation enhanced stimulus-selective mnemonic signal in individual anterior temporal neurons while leaving bottom-up perceptual signal unchanged. Furthermore, similar activity difference was also observed between correct and mnemonic error trials before silencing, suggesting its behavioral relevance. These multifaceted but convergent results provide a multiscale causal understanding of dynamic top-down regulation of the anterior temporal cortex along the ventral fronto-temporal network underpinning short-term object memory in primates. |
| 書誌情報 |
Nature communications
巻 15,
号 1,
p. 5369,
発行日 2024-07
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2041-1723 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
38987235 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41467-024-49570-w |
