| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-04 |
| タイトル |
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タイトル |
Uranium micro localization in the femur of rats exposed to uranium acetate |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kato Yugo
Yakumaru Haruko
Ayama Kyoko
Terauchi Miyu
Numako Chiya
Sekizawa Oki
Nitta Kiyofumi
Takeda Shino
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Uranium is a radionuclide that causes internal exposure, with the bone being one of its primary sites of retention. However, the precise localization of uranium within the bone is not well known. In this study, we analyzed the distribution of uranium in the femur of rats exposed to uranium. For our analysis, we used synchrotron radiation X-ray fluorescence analysis with high-energy excitation X-rays with microbeam (high-energy SR-μXRF). To quantify uranium in bone tissues, we modified our previously developed thin section standards. Additionally, we prepared droplet standards for quantifying bone calcium. Our findings showed that uranium concentration at bone sites was estimated to be 20% lower than at bone marrow sites of the same intensity, likely owing to matrix effects. The elemental mapping of the femur's frozen section specimens showed that uranium was distributed in a very limited surface layer bordering the bone marrow, one day post-administration. |
| 書誌情報 |
Microchemical Journal
巻 207,
p. 112278,
発行日 2024-11
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| 出版者 |
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出版者 |
ELSEVIER |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.microc.2024.112278 |
