WEKO3
アイテム
Low-invasive, wide-field, and cellular resolution two-photon imaging of neural population activity in brainstem and nucleus tractus solitarii.
https://repo.qst.go.jp/records/2001213
https://repo.qst.go.jp/records/20012137ea924d5-e79f-486d-8b2a-654a1ca24e44
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||
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| 公開日 | 2025-03-12 | |||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||
| タイトル | Low-invasive, wide-field, and cellular resolution two-photon imaging of neural population activity in brainstem and nucleus tractus solitarii. | |||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||
| 著者 |
Agetsuma Masakazu
× Agetsuma Masakazu
× Hatakeyama Azumi
× Daisuke Yamada
× Hiroshi Kuniishi
× Eri Takeuchi
× Shinji Tsuji
× Ito Chihiro
× Tomoko Kobayashi
× Atsushi Noritake
× Yoshitsugu Aoki
× Yukawa Hiroshi
× Akiyoshi Saitoh
× Junichi Nabekura
× Masayuki Sekiguchi
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||||
| 内容記述 | Brain-viscera communication is thought to play a crucial role in regulating mental health, with the vagus nerve being a key structure mediating this interaction. Clinically, artificial vagus nerve stimulation (VNS) is used to treat various neuropsychiatric disorders, highlighting the importance of vagal afferent fibers in regulating emotion. The nucleus tractus solitarii (NTS) is a brainstem structure proposed to receive direct signals from vagal afferents and relay them to the brain’s emotional regulatory networks. Direct evidence for this network is limited, however, due to the anatomic complexity and difficulty accessing the deep-brain NTS region in living animals. Here, to investigate this further, we developed a wide-field and deep-brain two-photon imaging method using a prism-based optical interface enabling the identification of cellular-resolution neural activities of the NTS while keeping the cerebellum, which covers the NTS, intact. This method allowed us to evaluate how NTS neurons respond to VNS and the gastrointestinal hormone cholecystokinin-8, suggesting its usefulness for investigating the role of the vagus-NTS pathway in regulating emotion. |
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| 書誌情報 |
biorxiv 発行日 2024-06 |
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||||||||
| 関連識別子 | 10.1101/2024.05.31.596631 | |||||||||||||||||||||||||||||||||
