| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-09-20 |
| タイトル |
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タイトル |
A Mechanism for Apoptotic Effects of a Planar Catechin Analog on Cancer Cells |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ito Hiromu
Shoji Yoshimi
Matsumoto Ken-ichiro
Fukuhara Kiyoshi
Nakanishi Ikuo
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Catechin is one of the representative antioxidants that shows physiological activities such as an anti-cancer effect. We have developed a chemically modified catechin analog possessing a planar structure, which shows an enhanced radical-scavenging activity as well as inhibitory effects on the proliferation and migration of cancer cells, compared to the parent (+)-catechin. In this study, the mechanism for cancer cell inhibition by the planar catechin was partly elucidated using a gastric cancer cell line. The planar catechin treatment induced an enhanced expression of an apoptotic marker, cleaved caspase-3, in addition to the mitigation of the intracellular accumulation of reactive oxygen species (ROS) and NF-κB expression. Furthermore, γH2AX, a marker of double-strand breaks in DNA, was also induced by the planar catechin treatment in a dose-dependent manner. These findings suggest that the removal of ROS by the planar catechin with a higher antioxidant ability executed NF-κB suppression and/or the planar catechin-injured DNA, leading to the induction of apoptosis in cancer cells. |
| 書誌情報 |
Molecules
巻 29,
号 18,
p. 4467,
発行日 2024-09
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| 出版者 |
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出版者 |
Multidisciplinary Digital Publishing Institute |
