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Radiolysis of myoglobin concentrated gels by protons: specific changes in secondary structure and production of carbon monoxide
https://repo.qst.go.jp/records/2001164
https://repo.qst.go.jp/records/20011641b95a63d-c943-4dca-9724-0eeb80fd5f08
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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| 公開日 | 2024-04-19 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Radiolysis of myoglobin concentrated gels by protons: specific changes in secondary structure and production of carbon monoxide | |||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
Nicolas Ludwig
× Nicolas Ludwig
× Catherine Galindo
× Clea Witjaksono
× Antoine Danvin
× Philippe Peaupardin
× Dominique Muller
× Kusumoto Tamon
× Kodaira Satoshi
× Remi Barillon
× Quentin Raffy
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||
| 内容記述 | While particle therapy has been used for decades for cancer treatment, there is still a lack of information on the molecular mechanisms of biomolecules radiolysis by accelerated ions. Here, we examine the effects of accelerated protons on highly concentrated native myoglobin, by means of Fourier transform infrared and UV?Visible spectroscopies. Upon irradiation, the secondary structure of the protein is drastically modified, from mostly alpha helices conformation to mostly beta elements at highest fluence. These changes are accompanied by significant production of carbon monoxide, which was shown to come from heme degradation under irradiation. The radiolytic yields of formation of denatured protein, carbon monoxide, and of heme degradation were determined, and found very close to each other: G+denatured Mb ~ G+CO ~ G-heme = 1.6 × 10?8 ± 0.1 × 10?8 mol/J = 0.16 ± 0.01 species/100 eV. The denaturation of the protein to a beta structure and the production of carbon monoxide under ion irradiation are phenomena that may play an important role in the biological effects of ionizing radiation. | |||||||||||||||||||||||||
| 書誌情報 |
Scientific Reports 巻 14, p. 8625, 発行日 2024-04 |
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| 出版者 | ||||||||||||||||||||||||||
| 出版者 | Nature Research | |||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||
| 関連識別子 | 10.1038/s41598-024-58378-z | |||||||||||||||||||||||||
