| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-04-16 |
| タイトル |
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タイトル |
Dose Rate Effects on Hydrated Electrons, Hydrogen Peroxide, and a OH Radical Molecular Probe Under Clinical Energy Protons |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kusumoto Tamon
Antoine Danvin
Mamiya Taisei
Aurelia Arnone
Severine Chefson
Catherine Galindo
Philippe Peaupardin
Quentin Raffy
Nagaaki Kamiguchi
Daizo Amano
Kenzo Sasai
Konishi Teruaki
Kodaira Satoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We report the dose rate dependence of radiation chemical yields (G value) of water radiolysis products under clinical energy protons (230 MeV) to understand mechanisms of the FLASH radiotherapy performed at ultra-high dose rate (>40 Gy/s). The G value of 7-hydoroxy-coumarin-3-carboxylic acid (7OH-C3CA) produced by reactions of coumarin-3-carboxylic acid (C3CA) with OH radicals and oxygen is evaluated by fluorescence method. Also, those of hydrated electrons and hydrogen peroxide are derived by absorption method using Saltzman and Ghomley techniques, respectively. Both G values of 7OH-C3CA and hydrated electrons decrease with increasing dose rate. The relative evolution of 7OH-C3CA is ?39 ± 2% between 0.1 and 50 Gy/s. This value is higher than that of hydrated electrons, measured at ?21 ± 4%. The G value of hydrogen peroxide in ultra-pure water also decreases with increasing dose rate. In comparison to these findings, we represent the increase of the G value of hydrogen peroxide with increasing dose rate in the mixture solution of MeOH and NaNO3, which act as scavengers of OH radicals and hydrated electrons, respectively, that decompose hydrogen peroxide. This finding indicates that a complex track structure can be expected with increasing dose rate and the reduction of OH radicals by forming hydrogen peroxide would be related to the sparing effect of healthy tissues. |
| 書誌情報 |
Radiation Research
巻 201,
号 4,
p. 287-293,
発行日 2024-04
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| 出版者 |
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出版者 |
Allen Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0033-7587 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1667/RADE-23-00244.1 |
