| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-24 |
| タイトル |
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タイトル |
Quantification of Oxygenation and Oxygen Consumption Rates in the Mouse Brain based on Tissue Oxygen Level-Dependent (TOLD) MRI |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Raj Kumar Parajuli
Megumi Ueno
Hiromi Sano
Shan Gao
Saaya Suzuki
Akira Sumiyoshi
Kensuke Osada
Takayuki Obata
Ichio Aoki
Ken-ichiro Matsumoto
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A non-invasive method to estimate oxygenation and oxygen (O2) consumption rates in mouse brain tissue based on T1-weighted tissue oxygen level-dependent (TOLD) MRI was developed. The aim of the present study was to estimate the kinetics of O2 in tissue in order to facilitate the planning of radiation therapy.
The relationship between the proton T1 relaxation rate and O2 concentrations was examined in water and corn oil samples, which are models of the aqueous and lipidic phases of cell components. T1 maps of the mouse brain were obtained under breathing high oxygen concentration gas, carbogen (95% O2 + 5% CO2), or 100% O2, and shifts in the concentration of O2 from the physiological state in the brain were then estimated. Pseudo-TOLD signals in blood samples, hemoglobin, and myoglobin aqueous solutions under oxygenation were measured to examine the effects of heme iron on T1. O2 metabolism in mouse brains was evaluated by the enhancement/diminishment rates of the TOLD signal when the breathing gas was switched from air to carbogen or 100% O2 and when it was switched back to air.
Carbogen or 100% O2 inhalation increased cortical O2 levels by 0.28 or 0.26 mmol/L, respectively. By analyzing the time course profile of the TOLD signal, the oxygenation rate, oxygenation level, and O2 consumption rate were successfully estimated. TOLD MRI has potential as a useful tool to estimate the quantitative indices of oxygenation and O2 consumption rates in brain tissue. |
| 書誌情報 |
NMR in Biomedicine
巻 38,
号 9,
p. e70104,
発行日 2025-07
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| 出版者 |
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出版者 |
WILEY Subscription Service Inc. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1099-1492 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
40693489 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1002/nbm.70104 |
Parajuli.RK.2025.NMR.Biomed.38(9).e70104.pdf (2.3 MB)
