| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-03-29 |
| タイトル |
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|
タイトル |
Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yudai Ode
Ambara R Pradipta
Akihiro Ishiwata
Akihiro Nambu
Kazunobu Ohnuki
Hiroshi Mizuma
Hiromitsu Haba
Katsunori Tanaka
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| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
This study proposes a new method for radionuclide therapy that involves the use of oligomeric 2,6-diisopropylphenyl azides and a chelator to form stable complexes with metallic radionuclides. The technique works by taking advantage of the endogenous acrolein produced by cancer cells. The azides react with the acrolein to give a diazo derivative that immediately attaches to the nearest organelle, effectively anchoring the radionuclide within the tumor. Preliminary experiments were conducted on a human lung carcinoma xenograft model, demonstrating the feasibility of this approach for cancer treatment. |
| 書誌情報 |
Chemical communications (Cambridge, England)
巻 60,
号 24,
p. 3291-3294,
発行日 2024-03
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1364-548X |
| PubMed番号 |
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|
識別子タイプ |
PMID |
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関連識別子 |
38421438 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1039/d4cc00048j |
