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The Effect of Steatosis on Shear-Wave Velocity and Viscoelastic Properties Related to Liver Fibrosis Progression in Rat Models
https://repo.qst.go.jp/records/2001105
https://repo.qst.go.jp/records/2001105e6edf133-7639-42ff-a6bc-a974822b5f3b
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2024-03-08 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | The Effect of Steatosis on Shear-Wave Velocity and Viscoelastic Properties Related to Liver Fibrosis Progression in Rat Models | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Tamura Kazuki
× Tamura Kazuki
× Ito Kazuyo
× Kishimoto Riwa
× Yoshida Kenji
× Kishimoto Takashi
× Obata Takayuki
× Yamaguchi Tadashi
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Objective Hepatic fibrosis has recently been evaluated using ultrasonography or magnetic resonance elastography. Although the shear wave velocity (SWV) obtained using point shear wave elastography (pSWE) provides a valuable measure of fibrosis, underlying steatosis may affect its measurement. Methods Using hepatic fibrosis samples, this study evaluated the effect of steatosis on the shear wave velocity of pSWE (Vs) and viscoelastic properties (assessed by dynamic mechanical analysis) of rat liver. Fifty rats with various grades of steatosis and fibrosis underwent open abdominal in vivo Vs measurements using a commercial ultrasound scanner. The mechanical properties of hepatic tissue were also characterized under ex vivo conditions using dynamic mechanical analysis and the Zener model of viscoelasticity. Results Fibrosis and steatosis progression influenced Vs and elasticity. The SWV computed using the Zener model and Vs showed a substantial correlation (r > 0.8). Fibrosis progression increased SWV. Steatosis was also related to SWV. Steatosis progression obscured the SWV change associated with fibrosis progression. Conclusion We conclude that steatosis progression affects the evaluation of fibrosis progression. This finding could aid discrimination of non-alcoholic steatohepatitis from non-alcoholic fatty liver disease using SWV. |
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| 書誌情報 |
Ultrasound in Medicine & Biology 巻 50, 発行日 2024-01 |
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| 出版者 | Elsevier | |||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 1879-291X | |||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | 38238201 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.1016/j.ultrasmedbio.2024.01.002 | |||||||||||||||||||
