| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-03-12 |
| タイトル |
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タイトル |
LET Dependence of 8-Hydroxy-2'-deoxyguanosine (8-OHdG) Generation in Mammalian Cells under Air-Saturated and Hypoxic Conditions: A Possible Experimental Approach to the Mechanism of the Decreasing Oxygen Effect in the High-LET Region |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ito Atsushi
Kitabatake Satomi
Furuichi Wataru
Takase Nobuhiro
Nakahara Tasuku
Akiyama Tatsuki
Shigeo Yoshida
Yosuke Kusano
Furusawa Yoshiya
Hirayama Ryoichi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
One of the most distinguished features in biological effects of heavy ions would be the decrease of oxygen effect in the high-LET region. This feature has been referred to as the radiobiological basis for the control of hypoxic fraction in cancer radiotherapy. However, mechanisms to explain this phenomenon have not been fully understood. One of the explanations was given by the oxygen in the track hypothesis, which proposes that oxygen is produced along ion tracks even in the hypoxic irradiation condition. In the present study, we designed an experimental approach to support this hypothesis by using 8-hydroxy-2'-deoxyguanosine (8-OHdG) as DNA damage requiring oxygen to produce. The LET dependence of 8-OHdG under hypoxic condition revealed that with increasing LET 8-OHdG yield seems to increase, despite that the yield of OH radical, which is also required for the production of 8-OHdG, decreases in the high-LET region. This result is consistent with the explanation that the local generation of oxygen along ion tracks contributes to the increase of 8-OHdG yield. |
| 書誌情報 |
Radiation Research
巻 201,
号 3,
p. 189-196,
発行日 2024-01
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| 出版者 |
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出版者 |
Radiation Research Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1938-5404 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
38294870 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1667/RADE-23-00046.1 |
