| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-02-01 |
| タイトル |
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|
タイトル |
A first-in-man study of [18F] FEDAC: a novel PET tracer for the 18-kDa translocator protein. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kentaro Tamura
Ryuichi Nishii
Kotaro Tani
Hiroki Hashimoto
Kazunori Kawamura
Ming-Rong Zhang
Takamasa Maeda
Kana Yamazaki
Tatsuya Higashi
Masahiro Jinzaki
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
N-benzyl-N-methyl-2-[7, 8-dihydro-7-(2-[F] fluoroethyl) -8-oxo-2-phenyl-9H-purin-9-yl] acetamide ([F] FEDAC) is a novel positron emission tomography (PET) tracer that targets the translocator protein (TSPO; 18 kDa) in the mitochondrial outer membrane, which is known to be upregulated in various diseases such as malignant tumors, neurodegenerative diseases, and neuroinflammation. This study presents the first attempt to use [F]FEDAC PET/CT and evaluate its biodistribution as well as the systemic radiation exposure to the radiotracer in humans. |
| 書誌情報 |
Annals of nuclear medicine
発行日 2024-01
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| 出版者 |
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出版者 |
Springer Japan |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1864-6433 |
| PubMed番号 |
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|
識別子タイプ |
PMID |
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関連識別子 |
38285284 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1007/s12149-023-01895-0 |
