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内容記述 |
Carbon ion radiotherapy (CIRT) is a heavy ion charge particle therapy with 29 years of prominent use. Despiteadvantages like high relative biological effectiveness (RBE), improved quality of life, and reduced treatmenttime, challenges persist, especially regarding heavy nuclear fragments. Our research addresses these challengesin horizontal irradiation, aiming to comprehend Monoenergetic and Spread-Out Bragg peak (SOBP) carbon ionbeam trajectories using cell survival analysis and visualizing biological effects through DNA damage (γ-H2AX).This reveals repair-related protein foci near the Bragg peak. CR-39, a plastic nuclear track detector, was exploredto understand high-linear energy transfer (LET) tracks and radiation quality near the Bragg peak. Findings unveilhigh-LET DNA damage signatures through aligned γ-H2AX foci, correlating with LET values in SOBP. CR-39 visu-alized high-LET particle exposure, indicating comet-type etch-pits at the Bragg peak and suggesting carbon ionfragmentation. Unexpectedly, dot-type etch-pits in irradiated and post-Bragg peak regions indicated high-LETneutron production. This investigation highlights the intricate interplay of carbon ion beams, stressing the im-portance of understanding LET variations, DNA damage patterns, and undesired secondary exposure. |
