| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-08 |
| タイトル |
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タイトル |
Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ito Hiromu
Shoji Yoshimi
Matsumoto Ken-ichiro
Fukuhara Kiyoshi
Nakanishi Ikuo
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Cancer cell migration is related to the malignancy and prognosis of patients. We previously reported that intracellular reactive oxygen species (ROS) promoted cancer cellular migration and invasion, and an antioxidant enzyme could help to attenuate the malignancy. Catechin is known as an antioxidant and we have developed a catechin analog, planar catechin, which showed a significantly stronger antioxidant activity than the parent (+)-catechin. In this study, we examined the effects of the planar catechin on the migration of gastric normal and cancer cells. A scratched assay showed that the planar catechin suppressed the cellular migration rates in both normal and cancer cells while the prevention levels in cancer cells were remarkable compared to the normal cells. These results suggest that the planar catechin with the enhanced antioxidant activity effectively scavenged the ROS overexpressed in the cancer cells and inhibited of cancer cellular activities including migration. |
| 書誌情報 |
ACS Medicinal Chemistry Letters
巻 15,
号 2,
p. 310-313,
発行日 2024-01
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| 出版者 |
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出版者 |
American Chemical Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1948-5875 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1021/acsmedchemlett.3c00499 |
