| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-21 |
| タイトル |
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タイトル |
Decomposition characteristics of a hypervalent iodine compound, 2-iodosobenzoic acid, exposed to monochromatic X-rays around the iodine L3-edge energy region |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ohara Maki
Izumi Yudai
Hideo Takakura
Shosei Enomoto
Fujii Kentaro
Yokoya Akinari
Mikako Ogawa
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
In clinical settings, the development of novel X-ray-activated caged compounds has been described as a key factor in both therapeutic and diagnostic applications to halt the action of specific medication, i.e., reactivation by external X-ray irradiation causing site-selective bond breakages, during delivery to target organs. In this work, we focused on a hypervalent iodine compound, namely 2-iodosobenzoic acid (IBA), as a candidate for the protecting group of X-ray-activated caged compounds, and investigated the decomposition reactions of IBA induced by X-ray irradiations around the iodine L3-edge energy region. Our results showed that X-irradiations induced bond breakages around the hypervalent iodine atom, and the associated decomposition rate was dependent on the irradiated X-ray photon energy. Particularly, X-ray absorption spectral changes and desorbed molecular fragments confirmed a significant molecular decomposition induced by one of the iodine L-shell excitations. Our findings suggest that the hypervalent iodine compound could be a very promising candidate for the design of novel X-ray-activated caged compounds. |
| 書誌情報 |
Radiation Physics and Chemistry
巻 216,
p. 111394,
発行日 2023-11
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2588-803X |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.radphyschem.2023.111394 |
