| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-09 |
| タイトル |
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タイトル |
Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Shuraku Son
Makoto Arai
Kazuya Toriumi
Christina Andica
Daisuke Matsuyoshi
Koji Kamagata
Shigeki Aoki
Takahiko Kawashima
Takanori Kochiyama
Tomohisa Okada
Yasutaka Fushimi
Yuji Nakamoto
Yuko Kobayashi
Toshiya Murai
Masanari Itokawa
Jun Miyata
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Carbonyl stress is a condition featuring increased rich reactive carbonyl compounds, which facilitate the formation of advanced glycation end products including pentosidine. We previously reported the relationship between enhanced carbonyl stress and disrupted white matter integrity in schizophrenia, although which microstructural component is disrupted remained unclear. In this study, 32 patients with schizophrenia (SCZ) and 45 age- and gender-matched healthy volunteers (HC) were recruited. We obtained blood samples for carbonyl stress markers (plasma pentosidine and serum pyridoxal) and multi-modal magnetic resonance imaging measures of white matter microstructures including apparent axonal density (intra-cellular volume fraction (ICVF)) and orientation (orientation dispersion index (ODI)), and inflammation (free water (FW)). In SCZ, the plasma pentosidine level was significantly increased. Group comparison revealed that mean white matter values were decreased for ICVF, and increased for FW. We found a significant negative correlation between the plasma pentosidine level and mean ICVF values in SCZ, and a significant negative correlation between the serum pyridoxal level and mean ODI value in HC, regardless of age. Our results suggest an association between enhanced carbonyl stress and axonal abnormality in SCZ. |
| 書誌情報 |
Scientific Reports
巻 13,
p. 12220,
発行日 2023-07
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| 出版者 |
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出版者 |
Macmillan Publishers Limited, part of Springer Nature |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
37500709 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-023-39379-w |
