| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-08 |
| タイトル |
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|
タイトル |
Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hiroshi Ikenuma
Aya Ogata
Hiroko Koyama
Bin Ji
Hideki Ishii
Takashi Yamada
Junichiro Abe
Chie Seki
Yuji Nagai
Masanori Ichise
Takafumi Minamimoto
Makoto Higuchi
Ming-Rong Zhang
Takashi Kato
Kengo Ito
Masaaki Suzuki
Yasuyuki Kimura
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer's disease (AD) has been reported; RIPK1 is involved in microglia's phenotypic transition to their dysfunctional states, and it is highly expressed in the neurons and microglia in the postmortem brains in AD patients. They prompt neurodegeneration leading to accumulations of pathological proteins in AD. Therefore, regulation of RIPK1 could be a potential therapeutic target for the treatment of AD, and in vivo imaging of RIPK1 may become a useful modality in studies of drug discovery and pathophysiology of AD. The purpose of this study was to develop a suitable radioligand for positron emission tomography (PET) imaging of RIPK1. |
| 書誌情報 |
EJNMMI radiopharmacy and chemistry
巻 8,
号 1,
p. 31,
発行日 2023-10
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2365-421X |
| PubMed番号 |
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|
識別子タイプ |
PMID |
|
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関連識別子 |
37853253 |
| DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1186/s41181-023-00217-z |
