| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-08 |
| タイトル |
|
|
タイトル |
A Method for Locally Irradiate Specific Tissue of Model Organisms using Focused Heavy-Ion Microbeam |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tomoo Funayama
Michiyo Suzuki
Nobumasa Miyawaki
Hirotsugu Kashiwagi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The functions of organisms are performed by various tissues composed of different cell types. Localized irradiation with heavy-ion microbeams, which inactivate only a portion of the constituent cells without destroying the physical intercellular connections of the tissue, is a practical approach for elucidating tissue functions. However, conventional collimated microbeams are limited in the shape of the area that can be irradiated. Therefore, using a focused heavy-ion microbeam that generates a highly precise beam spot, we developed a technology to uniformly irradiate specific tissues of an organism with a defined dose, which conventional methods cannot achieve. The performance of the developed paint irradiation technology was evaluated. By irradiating the CR-39 ion track detector, we confirmed that the new method, in which each ion hit position is placed uniformly in the irradiated area, makes it possible to uniformly paint the area at a specified dose. The targeted irradiation of the pharynx and gonads of living Caenorhabditis elegans demonstrated that the irradiated ions were distributed in the same shape as the targeted tissue observed under a microscope. This technology will elucidate biological mechanisms that are difficult to analyze with conventional collimated microbeam irradiation. |
| 書誌情報 |
Biology
巻 12,
号 12,
p. 1524,
発行日 2023-12
|
| 出版者 |
|
|
出版者 |
MDPI |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2079-7737 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/biology12121524 |
