| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-11 |
| タイトル |
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タイトル |
Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Katsunori Yogo
Kodaira Satoshi
Kusumoto Tamon
Kitamura Hisashi
Toshiyuki Toshito
Hiromitsu Iwata
Masumi Umezawa
Masashi Yamada
Takuto Miyoshi
Masataka Komori
Hiroshi Yasuda
Jun Kataoka
Seiichi Yamamoto
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective. FLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and precise dose distribution measurements remain difficult for FLASH radiation therapy with proton beams. To solve this problem, we performed luminescence imaging of water following irradiation by a UHDR proton beam captured using a charge-coupled device camera. Approach. We used 60 MeV proton beams with dose rates of 0.03?837 Gy s?1 from a cyclotron. Therapeutic 139.3 MeV proton beams with dose rates of 0.45?4320 Gy s?1 delivered by a synchrotron-based proton therapy system were also tested. The luminescent light intensity induced by the UHDR beams was compared with that produced by conventional beams to compare the dose rate dependency of the light intensity and its profile. Main results. Luminescence images of water were clearly visualized under UHDR conditions, with significantly shorter exposure times than those with conventional beams. The light intensity was linearly proportional to the delivered dose, which is similar to that of conventional beams. No significant dose-rate dependency was observed for 0.03?837 Gy s?1. The light-intensity profiles of the UHDR beams agreed with those of conventional beams. The results did not differ between accelerators (synchrotron or cyclotron) and beam energies. Significance. Luminescence imaging of water is achievable with UHDR proton beams as well as with conventional beams. The proposed method should be suitable for rapid and easy quality assurance investigations for proton FLASH therapy, because it facilitates real-time, filmless measurements of dose distributions, and is useful for rapid feedback. |
| 書誌情報 |
Physics in Medicine and Biology
巻 68,
p. 15NT02,
発行日 2023-07
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| 出版者 |
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出版者 |
IOP Publishing |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1361-6560 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1088/1361-6560/ace60b |
