| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-04 |
| タイトル |
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|
タイトル |
Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain. |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yasuharu Yamamoto
Keisuke Takahata
Manabu Kubota
Hiroyoshi Takeuchi
Sho Moriguchi
Takeshi Sasaki
Chie Seki
Hironobu Endo
Kiwamu Matsuoka
Kenji Tagai
Yasuyuki Kimura
Shin Kurose
Masaru Mimura
Kazunori Kawamura
Ming-Rong Zhang
Makoto Higuchi
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The topological distribution of dopamine-related proteins is determined by gene transcription and subsequent regulations. Recent research strategies integrating positron emission tomography with a transcriptome atlas have opened new opportunities to understand the influence of regulation after transcription on protein distribution. Previous studies have reported that messenger (m)-RNA expression levels spatially correlate with the density maps of serotonin receptors but not with those of transporters. This discrepancy may be due to differences in regulation after transcription between presynaptic and postsynaptic proteins, which have not been studied in the dopaminergic system. Here, we focused on dopamine D1 and D2/D3 receptors and dopamine transporters and investigated their region-wise relationship between mRNA expression and protein distribution. |
| 書誌情報 |
European journal of nuclear medicine and molecular imaging
巻 50,
p. 3928-3936,
発行日 2023-08
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| 出版者 |
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出版者 |
Springer Nature |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1619-7089 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
37581725 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s00259-023-06390-2 |
