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Comparing Oncologic Outcomes and Toxicity for Combined Modality Therapy vs. Carbon-Ion Radiotherapy for Previously Irradiated Locally Recurrent Rectal Cancer.
https://repo.qst.go.jp/records/2000676
https://repo.qst.go.jp/records/2000676a393d3b3-2356-4a09-b3df-6e9796dc164c
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||||||||||
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| 公開日 | 2024-09-30 | |||||||||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||||||||
| タイトル | Comparing Oncologic Outcomes and Toxicity for Combined Modality Therapy vs. Carbon-Ion Radiotherapy for Previously Irradiated Locally Recurrent Rectal Cancer. | |||||||||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||||||||
| 著者 |
Elizabeth B Jeans
× Elizabeth B Jeans
× Daniel K Ebner
× Hirotoshi Takiyama
× Kaitlin Qualls
× Danielle A Cunningham
× Mark R Waddle
× Krishan R Jethwa
× William S Harmsen
× Joleen M Hubbard
× Eric J Dozois
× Kellie L Mathis
× Hiroshi Tsuji
× Kenneth W Merrell
× Christopher L Hallemeier
× Anita Mahajan
× Shigeru Yamada
× Robert L Foote
× Michael G Haddock
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| 抄録 | ||||||||||||||||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||||||||||||
| 内容記述 | No standard treatment paradigm exists for previously irradiated locally recurrent rectal cancer (PILRRC). Carbon-ion radiotherapy (CIRT) may improve oncologic outcomes and reduce toxicity compared with combined modality therapy (CMT). Eighty-five patients treated at Institution A with CIRT alone (70.4 Gy/16 fx) and eighty-six at Institution B with CMT (30 Gy/15 fx chemoradiation, resection, intraoperative electron radiotherapy (IOERT)) between 2006 and 2019 were retrospectively compared. Overall survival (OS), pelvic re-recurrence (PR), distant metastasis (DM), or any disease progression (DP) were analyzed with the Kaplan-Meier model, with outcomes compared using the Cox proportional hazards model. Acute and late toxicities were compared, as was the 2-year cost. The median time to follow-up or death was 6.5 years. Median OS in the CIRT and CMT cohorts were 4.5 and 2.6 years, respectively ( ? 0.01). No difference was seen in the cumulative incidence of PR ( = 0.17), DM ( = 0.39), or DP ( = 0.19). Lower acute grade ? 2 skin and GI/GU toxicity and lower late grade ? 2 GU toxicities were associated with CIRT. Higher 2-year cumulative costs were associated with CMT. Oncologic outcomes were similar for patients treated with CIRT or CMT, although patient morbidity and cost were lower with CIRT, and CIRT was associated with longer OS. Prospective comparative studies are needed. | |||||||||||||||||||||||||||||||||||||||||
| 書誌情報 |
Cancers 巻 15, 号 11, p. 3057, 発行日 2023-06 |
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| 出版者 | MDPI | |||||||||||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||||||||
| 収録物識別子 | 2072-6694 | |||||||||||||||||||||||||||||||||||||||||
| PubMed番号 | ||||||||||||||||||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||||||||||||||||||
| 関連識別子 | 37297019 | |||||||||||||||||||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||||||||||||||||
| 関連識別子 | 10.3390/cancers15113057 | |||||||||||||||||||||||||||||||||||||||||
