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Toward standardization of tau PET imaging corresponding to various tau PET tracers: a multicenter phantom study
https://repo.qst.go.jp/records/2000644
https://repo.qst.go.jp/records/2000644c5b68d26-0a59-41ec-a156-3f997a16b773
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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| 公開日 | 2024-09-02 | |||||||||||||||||||||||||
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| タイトル | Toward standardization of tau PET imaging corresponding to various tau PET tracers: a multicenter phantom study | |||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
Wagatsuma Kei
× Wagatsuma Kei
× Miwa Kenta
× Akamatsu Go
× Yamao Tensho
× Kamitaka Yuto
× Sakurai Minoru
× Fujita Naotoshi
× Hanaoka Kohei
× Matsuda Hiroshi
× Ishii Kenji
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||
| 内容記述 | Objective Tau positron emission tomography (PET) imaging is a recently developed non-invasive tool that can detect the density and extension of tau neurofibrillary tangles. Tau PET tracers have been validated to harmonize and accelerate their development and implementation in clinical practice. Whereas standard protocols including injected dose, uptake time, and duration have been determined for tau PET tracers, reconstruction parameters have not been standardized. The present study conducted phantom experiments based on tau pathology to standardize quantitative tau PET imaging parameters and optimize reconstruction conditions of PET scanners at four Japanese sites according to the results of phantom experiments. Methods The activity of 4.0 and 2.0 kBq/mL for Hoffman 3D brain and cylindrical phantoms, respectively, was estimated from published studies of brain activity using [18F]flortaucipir, [18F]THK5351, and [18F]MK6240. We developed an original tau-specific volume of interest template for the brain based on pathophysiological tau distribution in the brain defined as Braak stages. We acquired brain and cylindrical phantom images using four PET scanners. Iteration numbers were determined as contrast and recover coefficients (RCs) in gray (GM) and white (WM) matter, and the magnitude of the Gaussian filter was determined from image noise. Results Contrast and RC converged at???4 iterations, the error rates of RC for GM and WM were?<?15% and 1%, respectively, and noise was?<?10% in Gaussian filters of 2?4 mm in images acquired using the four scanners. Optimizing the reconstruction conditions for phantom tau PET images acquired by each scanner improved contrast and image noise. Conclusions The phantom activity was comprehensive for first- and second-generation tau PET tracers. The mid-range activity that we determined could be applied to later tau PET tracers. We propose an analytical tau-specific VOI template based on tau pathophysiological changes in patients with AD to standardize tau PET imaging. Phantom images reconstructed under the optimized conditions for tau PET imaging achieved excellent image quality and quantitative accuracy. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 37, p. 494-503, 発行日 2023-05 |
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| 出版者 | Springer Nature | |||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 1864-6433 | |||||||||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||||||||
| 関連識別子 | 37243882 | |||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||
| 関連識別子 | 10.1007/s12149-023-01847-8 | |||||||||||||||||||||||||
