| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-07-18 |
| タイトル |
|
|
タイトル |
Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ikuhiko Nakase
Moe Miyai
Kosuke Noguchi
Mamoru Tamura
Yasuyuki Yamamoto
Nishimura Yushi
Mika Omura
Kot Hayashi
Shiroh Futaki
Shiho Tokonami
Takuya Iida
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The light-induced force and convection can be enhanced by the collective effect of electrons (superradiance and red shift) in high-density metallic nanoparticles, leading to macroscopic assembly of target molecules. We here demonstrate application of the light-induced assembly for drug delivery system with enhancement of cell membrane accumulation and penetration of biofunctional molecules including cell-penetrating peptides (CPPs) with superradiance-mediated photothermal convection. For induction of photothermal assembly around targeted living cells in cell culture medium, infrared continuous-wave laser light was focused onto high-density gold-particle-bound glass bottom dishes exhibiting plasmonic superradiance or thin gold-film-coated glass bottom dishes. In this system, the biofunctional molecules can be concentrated around the targeted living cells and internalized into them only by 100 s laser irradiation. Using this simple approach, we successfully achieved enhanced cytosolic release of the CPPs and apoptosis induction using a pro-apoptotic domain with a very low peptide concentration (nM level) by light-induced condensation. |
| 書誌情報 |
Nano Letters
巻 22,
号 24,
p. 9805-9814,
発行日 2022-12
|
| 出版者 |
|
|
出版者 |
ACS Publications |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1530-6992 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1021/acs.nanolett.2c02437 |
