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Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
https://repo.qst.go.jp/records/2000533
https://repo.qst.go.jp/records/20005335667cafb-313b-4c1a-b10e-b1a2b1b36e84
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||
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| 公開日 | 2024-07-05 | |||||||||||||||||||||||||||
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| タイトル | Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 著者 |
Kudo Takehiro
× Kudo Takehiro
× Takuwa Hiroyuki
× Manami Takahashi
× Urushihata Takuya
× Shimojo Masafumi
× Kazuaki Sampei
× Mitsugu Yamanaka
× Tomita Yutaka
× Sahara Naruhiko
× Suhara Tetsuya
× Higuchi Makoto
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||
| 内容記述 | In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of hyperexcitability. However, it is still unknown how INs are functionally affected in tau pathology, which is a major pathology in AD. To clarify this, we evaluated the neuronal activity of cortical INs in 6-month-old rTg4510 mice, a model of tauopathy. Calcium imaging with mDlx enhancer-driven labeling revealed that neuronal activity in INs was decreased in rTg4510 mice. In the patch clamp recording, the firing properties of fast-spiking INs were altered so as to reduce their activity in rTg4510 mice. In parallel with microglial activation, perineuronal nets around parvalbumin-positive INs were partially disrupted in rTg4510 mice. Taken together, our data indicate that the excitability of cortical fast-spiking INs is decreased, possibly due to the disruption of perineuronal nets. | |||||||||||||||||||||||||||
| 書誌情報 |
iScience 巻 26, 号 4, p. 106342, 発行日 2023-03 |
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| 出版者 | Cell Press | |||||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 2589-0042 | |||||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||
| 関連識別子 | 10.1016/j.isci.2023.106342 | |||||||||||||||||||||||||||
