| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-06-12 |
| タイトル |
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タイトル |
Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Keiji Suzuki
Tatsuhiko Imaoka
Masanori Tomita
Megumi Sasatani
Kazutaka Doi
Satoshi Tanaka
Michiaki Kai
Yutaka Yamada
Shizuko Kakinuma
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
While epidemiological data have greatly contributed to the estimation of the dose and dose-rate effectiveness factor (DDREF) for human populations, studies using animal models have made significant contributions to provide quantitative data with mechanistic insights. The current article aims at compiling the animal studies, specific to rodents, with reference to the dose-rate effects of cancer development. This review focuses specifically on the results that explain the biological mechanisms underlying dose-rate effects and their potential involvement in radiation-induced carcinogenic processes. Since the adverse outcome pathway (AOP) concept together with the key events holds promise for improving the estimation of radiation risk at low doses and low dose-rates, the review intends to scrutinize dose-rate dependency of the key events in animal models and to consider novel key events involved in the dose-rate effects, which enables identification of important underlying mechanisms for linking animal experimental and human epidemiological studies in a unified manner. |
| 書誌情報 |
Journal of radiation research
巻 64,
号 2,
p. 228-249,
発行日 2023-02
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-9157 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
36773331 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1093/jrr/rrad003 |
