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Evaluation of L-Alanine Metabolism in Bacteria and Whole-Body Distribution with Bacterial Infection Model Mice
https://repo.qst.go.jp/records/2000495
https://repo.qst.go.jp/records/2000495afd1b9ac-1094-405d-ac36-88b518eee74b
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||
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| 公開日 | 2024-05-23 | |||||||||||||||||||||||||||||||||
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| タイトル | Evaluation of L-Alanine Metabolism in Bacteria and Whole-Body Distribution with Bacterial Infection Model Mice | |||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||
| 著者 |
Muranaka Yuka
× Muranaka Yuka
× Matsue Miki
× 水谷 明日香
× 小林 正和
× Sato Kakeru
× Kondo Ami
× Nishiyama Yuri
× Ohata Shusei
× Nishi Kodai
× 山崎 香奈
× 西井 龍一
× Shikano Naoto
× Okamoto Shigefumi
× 川井 恵一
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||||
| 内容記述 | The World Health Organization has cautioned that antimicrobial resistance (AMR) will be responsible for an estimated 10 million deaths annually by 2050. To facilitate prompt and accurate diagnosis and treatment of infectious disease, we investigated the potential of amino acids for use as indicators of bacterial growth activity by clarifying which amino acids are taken up by bacteria during the various growth phases. In addition, we examined the amino acid transport mechanisms that are employed by bacteria based on the accumulation of labeled amino acids, Na+ dependence, and inhibitory effects using a specific inhibitor of system A.We found that 3H-L-Ala accurately reflects the proliferative activity of Escherichia coli K-12 and pathogenic EC-14 in vitro. This accumulation in E. coli could be attributed to the amino acid transport systems being different from those found in human tumor cells. Moreover, biological distribution assessed in infection model mice with EC-14 using 3H-L-Ala showed that the ratio of 3H-L-Ala accumulated in infected muscle to that in control muscle was 1.20. By detecting the growth activity of bacteria in the body that occurs during the early stages of infection by nuclear imaging, such detection methods may result in expeditious diagnostic treatments for infectious diseases. |
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| 書誌情報 |
International Journal of Molecular Sciences 巻 24, 号 5, p. 4775, 発行日 2023-03 |
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| 出版者 | MDPI | |||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||
| 収録物識別子 | 1422-0067 | |||||||||||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||||||||
| 関連識別子 | 10.3390/ijms24054775 | |||||||||||||||||||||||||||||||||
