| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-01-25 |
| タイトル |
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|
タイトル |
Parental competition for the regulators of chromatin dynamics in mouse zygotes. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Masatoshi Ooga
Rei Inoue
Kousuke Kazama
Sayaka Wakayama
Kamimura Satoshi
Teruhiko Wakayama
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The underlying mechanism for parental asymmetric chromatin dynamics is still unclear. To reveal this, we investigate chromatin dynamics in parthenogenetic, androgenic, and several types of male germ cells-fertilized zygotes. Here we illustrate that parental conflicting role mediates the regulation of chromatin dynamics. Sperm reduces chromatin dynamics in both parental pronuclei (PNs). During spermiogenesis, male germ cells acquire this reducing ability and its resistance. On the other hand, oocytes can increase chromatin dynamics. Notably, the oocytes-derived chromatin dynamics enhancing ability is dominant for the sperm-derived opposing one. This maternal enhancing ability is competed between parental pronuclei. Delayed fertilization timing is critical for this competition and compromises parental asymmetric chromatin dynamics and zygotic transcription. Together, parental competition for the maternal factor enhancing chromatin dynamics is a determinant to establish parental asymmetry, and paternal repressive effects have supporting roles to enhance asymmetry. |
| 書誌情報 |
Communications biology
巻 5,
号 1,
p. 699,
発行日 2022-07
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| 出版者 |
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出版者 |
Springer Nature |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2399-3642 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1038/s42003-022-03623-2 |
