| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-10-20 |
| タイトル |
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タイトル |
Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) in the brain |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yamasaki Tomoteru
Ishii Hideki
Hiraishi Atsuto
Kumata Katsushi
Wakizaka Hidekatsu
Yiding Zhang
Yusuke Kurihara
Ogawa Masanao
Nengaki Nobuki
Chen Jiahui
Li Yinlong
Liang Steven
Zhang Ming-Rong
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) mediates various AMPA receptor functions. Recently, [11C]TARP-2105 was developed as a PET ligand for TARP γ-8 imaging. We performed a full kinetic analysis of [11C]TARP-2105 using PET with [11C]TARP-2105 for the first time. The distribution volume (VT), which is a macro parameter consisting of the K1?k4 rate constants in the two-tissue compartment model analysis, exhibited the following rank order: hippocampus (1.4 ± 0.3) > amygdala (1.0 ± 0.2) > frontal cortex (0.9 ± 0.2) > striatum (0.8 ± 0.2) >> cerebellum (0.5 ± 0.1) ? thalamus (0.5 ± 0.1) > pons (0.4 ± 0.1 mL/cm3). These heterogenous VT values corresponded with the order of biological distribution of TARP γ-8 in the brain. To validate the reference tissue model, the binding potential (BPND) of [11C]TARP-2105 for TARP γ-8 was estimated using general methods (SRTM, MRTM0, Logan reference model, and ratio method). These reference models indicated excellent correlation (R2 > 0.9) to the indirect kinetic method with moderate reproducibility (%variability ? 10). PET with [11C]TARP-2105 enabled noninvasive BPND estimation and visual mapping of TARP γ-8 in the living rat brain. |
| 書誌情報 |
Journal of Cerebral Blood Flow & Metabolism
巻 43,
号 6,
p. 893-904,
発行日 2023-01
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| 出版者 |
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出版者 |
Sage Journals |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1559-7016 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1177/0271678X231152025 |
