| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-08-07 |
| タイトル |
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タイトル |
Synthesis of Small Peptide Nanogels Using Radiation Crosslinking as a Platform for Nano-Imaging Agents for Pancreatic Cancer Diagnosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kimura Atsushi
Arai Tadashi
Ueno Miho
Oyama Kotaro
Hao Yu
Shinichi Yamashita
Otome Yudai
Taguchi Mitsumasa
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Nanoparticle-based drug delivery systems (DDS) have been developed as effective diagnostic and low-dose imaging agents. Nano-imaging agents with particles greater than 100 nm are difficult to accumulate in pancreatic cancer cells, making high-intensity imaging of pancreatic cancer chal-lenging. Peptides composed of histidine and glycine were designed and synthesized. Additionally, aqueous peptide solutions were irradiated with γ-rays to produce peptide nanogels with an av-erage size of 25?53 nm. The mechanisms underlying radiation-mediated peptide crosslinking were investigated by simulating peptide particle formation based on rate constants. The rate constants for reactions between peptides and reactive species produced by water radiolysis were measured using pulse radiolysis. HGGGHGGGH (H9, H?histidine; G?glycine) particles exhibited a smaller size, as well as high formation yield, stability, and biodegradability. These particles were labeled with fluorescent dye to change their negative surface potential and enhance their accu-mulation in pancreatic cancer cells. Fluorescent-labeled H9 particles accumulated in PANC1 human pancreatic cancer cells, demonstrating that these particles are effective nano-imaging agents for intractable cancers. |
| 書誌情報 |
Pharmaceutics
巻 14,
号 11,
p. 2400,
発行日 2022-11
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| 出版者 |
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出版者 |
MDPI |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1999-4923 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.3390/pharmaceutics14112400 |
