| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-07-07 |
| タイトル |
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|
タイトル |
Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Etsuko Imabayashi
Yuji Saitoh
Tadashi Tsukamoto
Masuhiro Sakata
Harumasa Takano
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| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The Alzheimer disease (AD) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 18F-THK5351 is a first-generation PET tau tracer that also binds to monoamine oxidase B, which represents astrogliosis, and is useful to evaluate some non-AD neurodegenerative disorders. We examined the utility of 18F-THK5351 in preclinical AD using 3-dimensional stereotactic surface projection images optimized for its pathological accumulation by comparison with a normal dataset. By using this 18F-THK5351 3-dimensional stereotactic surface projection procedure, which can evaluate phosphorylated tau and neuroinflammation, we could diagnose preclinical AD effectively. |
| 書誌情報 |
Clinical nuclear medicine
巻 47,
号 12,
p. 1066-1068,
発行日 2022-09
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| 出版者 |
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出版者 |
Wolters Kluwer Health |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1536-0229 |
| PubMed番号 |
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|
識別子タイプ |
PMID |
|
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関連識別子 |
36179331 |
| DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1097/RLU.0000000000004425 |
