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[S-methyl-11C]-L-methionine positron emission tomography/computed tomography imaging parameters to evaluate early response for esophageal cancer with neoadjuvant carbon ion radiotherapy
https://repo.qst.go.jp/records/2000222
https://repo.qst.go.jp/records/2000222933902c6-8d58-44ec-ba53-638dfb184561
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||||
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| 公開日 | 2023-06-28 | |||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||
| タイトル | [S-methyl-11C]-L-methionine positron emission tomography/computed tomography imaging parameters to evaluate early response for esophageal cancer with neoadjuvant carbon ion radiotherapy | |||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||
| 著者 |
Narushima Kazuo
× Narushima Kazuo
× Nishii Ryuichi
× Okazumi Shinichi
× Shimada Hideaki
× Akutsu Yasunori
× Maeda Takamasa
× Yasuda Shigeo
× Yamada Shigeru
× Shuto Kiyohiko
× Tamura Kentaro
× Yamazaki Kana
× Shinoto Makoto
× Ishikawa Hitoshi
× Mori Mikito
× Hisahiro Matsubara
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| 抄録 | ||||||||||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||||||
| 内容記述 | This study aimed to evaluate the uptake of the clinical effectiveness of [S-methyl-11C]-L-methionine positron emission tomography/computed tomography (MET PET/CT) in patients with esophageal cancer and to investigate MET PET/CT imaging parameters to assess early response for esophageal cancer with neoadjuvant carbon ion radiotherapy (CIRT). MET PET/CT scans were performed in nineteen patients before and 3 weeks after completion of CIRT. After Surgery, the effect of neoadjuvant CIRT was investigated by examining the relationship between each parameter of MET uptake and the histological assessment (grade and tumor residual ratio). Four parameters of MET uptake were the maximum and minimum standardized uptake values of pre and post CIRT (pre-SUVmax, pre-SUVmean, post-SUVmax, and post-SUVmean). MET PET/CT imaging of esophageal cancer was clearly demonstrated. The post-SUVmax was the most suitable parameter. When the cutoff value was set as post-SUVmax = 6.21, the sensitivity, the specificity, and the accuracy of Grades 3 were 100.0%, 63.6%, and 78.9%, respectively. And there was a positive relationship between the tumor residual ratio and post-SUVmax (R2 = 0.38, p < 0.005). MET PET/CT is clinically useful for the assessment of early response to neoadjuvant CIRT in esophageal cancer. Particularly, post-SUVmax is considered a promising PET imaging parameter. | |||||||||||||||||||||||||||||||||||
| 書誌情報 |
Scientific Report 巻 12, 号 1, p. 13694, 発行日 2022-08 |
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| 出版者 | ||||||||||||||||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||||||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||||||||||||||||||
| 関連識別子 | 35953702 | |||||||||||||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||||||||||||
| 関連識別子 | 10.1038/s41598-022-17962-x | |||||||||||||||||||||||||||||||||||
