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Precise quantitative evaluation of pharmacokinetics of cisplatin using a radio-platinum tracer in tumor-bearing mice
https://repo.qst.go.jp/records/2000221
https://repo.qst.go.jp/records/20002219e0359fd-f4b9-47d9-a069-043685476467
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2023-06-28 | |||||||||||||||||||||
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| タイトル | Precise quantitative evaluation of pharmacokinetics of cisplatin using a radio-platinum tracer in tumor-bearing mice | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 著者 |
Obata Honoka
× Obata Honoka
× Tsuji Atsushi
× Sudo Hitomi
× Sugyo Aya
× Minegishi Katsuyuki
× Nagatsu Kotaro
× Ogawa Mikako
× Zhang Ming-Rong
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Objective The platinum-based antineoplastic drug cisplatin is commonly used for chemotherapy in clinics. This work aims to demonstrate a radio-platinum tracer is useful for precisely quantifying small amounts of platinum in pharmacokinetics studies. Methods A cisplatin radiotracer (radio-cisplatin) was synthesized, and a comprehensive evaluation of cisplatin over 7 days after its intravenous injection into nude mice bearing a subcutaneous lung tumor (H460) was conducted. Results A biphasic retention curve in the whole body and blood was observed [T1/2(α) = 1.14 h, T1/2(β) = 5.33 days for the whole body, and T1/2(α) = 23.9 min, T1/2(β) = 4.72 days for blood]. The blood concentration decreased within 1 day after injection. Most of the intact cisplatin was excreted via the kidneys in the early time points, and a small part was distributed in tissues including tumors. The plasma protein binding rate of cisplatin increased rapidly after injection, and the protein-bound cisplatin remained in the blood longer than intact cisplatin. The peak uptake in H460 tumors was 4.7% injected dose per gram at 15 min after injection, and the area under the curve (AUC0?7 days) was approximately onehalf to one-third of the AUC0?7 days in the kidneys, liver, and bone, where some toxicity is observed in humans. Conclusion The radio-platinum tracer revealed the highly quantitative biodistribution of cisplatin, providing insights into the properties of cisplatin, including its adverse effects. The tracer enables a precise evaluation of pharmacokinetics for platinum-based drugs with high sensitivity. Nucl Med Commun XXX: 000?000 Copyright c 2022 The Author(s). Published by Wolters Kluwer Health, Inc. |
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| 書誌情報 |
Nuclear Medicine Communications 巻 43, 号 11, p. 1121-1127, 発行日 2022-11 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 1473-5628 | |||||||||||||||||||||
| PubMed番号 | ||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||
| 関連識別子 | 36120823 | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | 10.1097/MNM.0000000000001614 | |||||||||||||||||||||
