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Scandium triflate-catalyzed N-[18F]Fluoroalkylation of aryl- or heteroaryl-amines with [18F]epifluorohydrin under mild condi-tions
https://repo.qst.go.jp/records/86196
https://repo.qst.go.jp/records/861966d66bc4e-6632-4bde-9763-019fc7551aef
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-23 | |||||
| タイトル | ||||||
| タイトル | Scandium triflate-catalyzed N-[18F]Fluoroalkylation of aryl- or heteroaryl-amines with [18F]epifluorohydrin under mild condi-tions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Masayuki, Fujinaga
× Masayuki, Fujinaga× Ohkubo, Takayuki× Tomoteru, Yamasaki× Katsushi, Kumata× Nobuki, Nengaki× Zhang, Ming-Rong× Masayuki, Fujinaga× Ohkubo, Takayuki× Tomoteru, Yamasaki× Katsushi, Kumata× Nobuki, Nengaki× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Scandium triflate-catalyzed N-[18F]fluoroalkylation of aryl- or heteroaryl-amines with [18F]epifluorohydrin ([18F]2) was investigated. This reaction is mild and provides one-step access to N-[18F]fluoroalkylated aryl- or heteroaryl-amines, which are used for positron emission tomography imaging. Use of 2,2,2-trifluoroethanol as a cosolvent improved the re-action efficiency. The use of (S)- or (R)-[18F]2 produced the corresponding enantiomeric N-[18F]fluoroalkylated anilines. | |||||
| 書誌情報 |
Organic Letters 巻 24, p. 4024-4028, 発行日 2022-05 |
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| 出版者 | ||||||
| 出版者 | American Chemical Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1523-7052 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acs.orglett.2c01459 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1021/acs.orglett.2c01459 | |||||
