WEKO3
アイテム
{"_buckets": {"deposit": "0415fb1e-6e59-453d-8be2-33b0db71ff26"}, "_deposit": {"created_by": 1, "id": "86025", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "86025"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00086025", "sets": ["1"]}, "author_link": ["1044295", "1044306", "1044309", "1044305", "1044307", "1044308", "1044296", "1044300", "1044294", "1044301", "1044302", "1044303", "1044304", "1044298", "1044310", "1044297", "1044299"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-04", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{"bibliographic_title": "Carcinogenesis"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Epidemiological studies have revealed a radiation-related increase in the risk of developing acute lymphoblastic leukemia (ALL). Our recent study revealed early induction and increased risk of precursor B-cell (pB) lymphomas in mice after radiation exposure. However, the genomic landscape of radiation-induced B-cell lymphomas remains unclear. To identify the relevant genetic alterations in mice, whole-exome sequencing was performed on both early-onset and late-onset B-cell lymphomas that developed spontaneously or after gamma-irradiation. In addition to multiple driver mutations, the data revealed that interstitial deletion of chromosome 4, including Pax5, and missense mutations in Jak3 are unique genomic alterations in radiation-induced, early-onset B-cell lymphomas. RNA sequencing revealed a pB-cell-type gene-expression profile with no involvement of known fusion genes for human ALLs in the early-onset B-cell lymphomas. Activation of Jak3/Stat5 signaling in early-onset B-cell lymphomas was validated using western capillary electrophoresis. Those features were similar to those of Philadelphia chromosome–like ALL. Our data suggest a critical role for Pax5 loss-of-function mutations in initiating B-cell leukemogenesis coupled with activation of Jak3/Stat5 signaling as a basis for the rapid development of radiation-induced pB-ALL. These molecular signatures for radiation-induced cancers will inform both risk assessment and potential targeted therapies for pB-ALL.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "35395675", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/carcin/bgac034.", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgac034/6565633?login=true", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1460-2180", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hirotaka, Tachibana"}], "nameIdentifiers": [{"nameIdentifier": "1044294", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kazuhiro, Daino"}], "nameIdentifiers": [{"nameIdentifier": "1044295", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Atsuko, Ishikawa"}], "nameIdentifiers": [{"nameIdentifier": "1044296", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takamitsu, Morioka"}], "nameIdentifiers": [{"nameIdentifier": "1044297", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yi, Shang"}], "nameIdentifiers": [{"nameIdentifier": "1044298", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mari, Ogawa"}], "nameIdentifiers": [{"nameIdentifier": "1044299", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akira, Matsuura"}], "nameIdentifiers": [{"nameIdentifier": "1044300", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshiya, Shimada"}], "nameIdentifiers": [{"nameIdentifier": "1044301", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shizuko, Kakinuma"}], "nameIdentifiers": [{"nameIdentifier": "1044302", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirotaka, Tachibana", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044303", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kazuhiro, Daino", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044304", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Atsuko, Ishikawa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takamitsu, Morioka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044306", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yi, Shang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044307", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mari, Ogawa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044308", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshiya, Shimada", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044309", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shizuko, Kakinuma", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1044310", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/86025", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-12-03"}, "publish_date": "2021-12-03", "publish_status": "0", "recid": "86025", "relation": {}, "relation_version_is_last": true, "title": ["Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans"], "weko_shared_id": -1}
Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans
https://repo.qst.go.jp/records/86025
https://repo.qst.go.jp/records/8602508b30a8e-7654-4621-9d99-ae4bbbeb3d90
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-12-03 | |||||
タイトル | ||||||
タイトル | Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hirotaka, Tachibana
× Hirotaka, Tachibana× Kazuhiro, Daino× Atsuko, Ishikawa× Takamitsu, Morioka× Yi, Shang× Mari, Ogawa× Akira, Matsuura× Yoshiya, Shimada× Shizuko, Kakinuma× Hirotaka, Tachibana× Kazuhiro, Daino× Atsuko, Ishikawa× Takamitsu, Morioka× Yi, Shang× Mari, Ogawa× Yoshiya, Shimada× Shizuko, Kakinuma |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epidemiological studies have revealed a radiation-related increase in the risk of developing acute lymphoblastic leukemia (ALL). Our recent study revealed early induction and increased risk of precursor B-cell (pB) lymphomas in mice after radiation exposure. However, the genomic landscape of radiation-induced B-cell lymphomas remains unclear. To identify the relevant genetic alterations in mice, whole-exome sequencing was performed on both early-onset and late-onset B-cell lymphomas that developed spontaneously or after gamma-irradiation. In addition to multiple driver mutations, the data revealed that interstitial deletion of chromosome 4, including Pax5, and missense mutations in Jak3 are unique genomic alterations in radiation-induced, early-onset B-cell lymphomas. RNA sequencing revealed a pB-cell-type gene-expression profile with no involvement of known fusion genes for human ALLs in the early-onset B-cell lymphomas. Activation of Jak3/Stat5 signaling in early-onset B-cell lymphomas was validated using western capillary electrophoresis. Those features were similar to those of Philadelphia chromosome–like ALL. Our data suggest a critical role for Pax5 loss-of-function mutations in initiating B-cell leukemogenesis coupled with activation of Jak3/Stat5 signaling as a basis for the rapid development of radiation-induced pB-ALL. These molecular signatures for radiation-induced cancers will inform both risk assessment and potential targeted therapies for pB-ALL. | |||||
書誌情報 |
Carcinogenesis 発行日 2022-04 |
|||||
出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1460-2180 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 35395675 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/carcin/bgac034. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgac034/6565633?login=true |