{"created":"2023-05-15T15:03:29.672361+00:00","id":86025,"links":{},"metadata":{"_buckets":{"deposit":"0415fb1e-6e59-453d-8be2-33b0db71ff26"},"_deposit":{"created_by":1,"id":"86025","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86025"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086025","sets":["1"]},"author_link":["1044295","1044306","1044309","1044305","1044307","1044308","1044296","1044300","1044294","1044301","1044302","1044303","1044304","1044298","1044310","1044297","1044299"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Carcinogenesis"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epidemiological studies have revealed a radiation-related increase in the risk of developing acute lymphoblastic leukemia (ALL). Our recent study revealed early induction and increased risk of precursor B-cell (pB) lymphomas in mice after radiation exposure. However, the genomic landscape of radiation-induced B-cell lymphomas remains unclear. To identify the relevant genetic alterations in mice, whole-exome sequencing was performed on both early-onset and late-onset B-cell lymphomas that developed spontaneously or after gamma-irradiation. In addition to multiple driver mutations, the data revealed that interstitial deletion of chromosome 4, including Pax5, and missense mutations in Jak3 are unique genomic alterations in radiation-induced, early-onset B-cell lymphomas. RNA sequencing revealed a pB-cell-type gene-expression profile with no involvement of known fusion genes for human ALLs in the early-onset B-cell lymphomas. Activation of Jak3/Stat5 signaling in early-onset B-cell lymphomas was validated using western capillary electrophoresis. Those features were similar to those of Philadelphia chromosome–like ALL. Our data suggest a critical role for Pax5 loss-of-function mutations in initiating B-cell leukemogenesis coupled with activation of Jak3/Stat5 signaling as a basis for the rapid development of radiation-induced pB-ALL. These molecular signatures for radiation-induced cancers will inform both risk assessment and potential targeted therapies for pB-ALL.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35395675","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/carcin/bgac034.","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgac034/6565633?login=true","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1460-2180","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirotaka, Tachibana"}],"nameIdentifiers":[{"nameIdentifier":"1044294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhiro, Daino"}],"nameIdentifiers":[{"nameIdentifier":"1044295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuko, Ishikawa"}],"nameIdentifiers":[{"nameIdentifier":"1044296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamitsu, Morioka"}],"nameIdentifiers":[{"nameIdentifier":"1044297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yi, Shang"}],"nameIdentifiers":[{"nameIdentifier":"1044298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mari, Ogawa"}],"nameIdentifiers":[{"nameIdentifier":"1044299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akira, Matsuura"}],"nameIdentifiers":[{"nameIdentifier":"1044300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshiya, Shimada"}],"nameIdentifiers":[{"nameIdentifier":"1044301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shizuko, Kakinuma"}],"nameIdentifiers":[{"nameIdentifier":"1044302","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirotaka, Tachibana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044303","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhiro, Daino","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044304","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuko, Ishikawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamitsu, Morioka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044306","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yi, Shang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044307","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mari, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshiya, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044309","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shizuko, Kakinuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1044310","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-03"},"publish_date":"2021-12-03","publish_status":"0","recid":"86025","relation_version_is_last":true,"title":["Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome–like acute lymphoblastic leukemia in humans"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:18:09.338854+00:00"}