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In vivo PET imaging of cancer α5β1-integrin using a pegylated peptide
https://repo.qst.go.jp/records/83860
https://repo.qst.go.jp/records/83860ed1472aa-4ac6-413b-8525-4215611cfff7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-01 | |||||
| タイトル | ||||||
| タイトル | In vivo PET imaging of cancer α5β1-integrin using a pegylated peptide | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× 謝, 琳× 張, 一鼎× 破入, 正行× 張, 明栄× Kuan, Hu× Lin, Xie× Zhang, Yiding× Masayuki, Hanyu× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives Integrin α5β1 is considered one of the most prominent targets among RGD binding integrin receptors for tumor diagnosis. Our goal is to develop a peptide-based radiotracer for PET imaging of α5β1-integrin in different types of cancers. Methods A peptide, with a sequence of KSSPHSRN(SG)5RGDSP (PR_b), was conjugated with a PEG molecule to obtain [64Cu]PEG-PR_b. PET imaging was performed in tumor-bearing mice. Ex vivo biodistribution and immunohistochemistry were employed to study the metabolism and specificity of the tracer. Results PET imaging revealed a higher tumor uptake of [64Cu]PEG-PR_b than that of [64Cu]PR_b (3.5%ID/g versus 1.8%ID/g) at 1 hour postinjection. Ex vivo biodistribution indicated that PEGylation delayed the kidney clearance of the tracers. Conclusion We anticipated clinical applicability of [64Cu]PEG-PR_b for imaging of α5β 1 by PET. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第61回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-04 | |||||
| 日付タイプ | Issued | |||||
