{"created":"2023-05-15T15:01:49.524378+00:00","id":83860,"links":{},"metadata":{"_buckets":{"deposit":"d4a70bfa-a564-40f7-afe6-8cd5b7ea9325"},"_deposit":{"created_by":1,"id":"83860","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83860"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083860","sets":["10:29"]},"author_link":["1011725","1011720","1011724","1011719","1011718","1011726","1011721","1011722","1011723","1011727"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives\nIntegrin α5β1 is considered one of the most prominent targets among RGD binding integrin receptors for tumor diagnosis. Our goal is to develop a peptide-based radiotracer for PET imaging of α5β1-integrin in different types of cancers.\n\nMethods\nA peptide, with a sequence of KSSPHSRN(SG)5RGDSP (PR_b), was conjugated with a PEG molecule to obtain [64Cu]PEG-PR_b. PET imaging was performed in tumor-bearing mice. Ex vivo biodistribution and immunohistochemistry were employed to study the metabolism and specificity of the tracer.\n\nResults\nPET imaging revealed a higher tumor uptake of [64Cu]PEG-PR_b than that of [64Cu]PR_b (3.5%ID/g versus 1.8%ID/g) at 1 hour postinjection. Ex vivo biodistribution indicated that PEGylation delayed the kidney clearance of the tracers.\n\nConclusion\nWe anticipated clinical applicability of [64Cu]PEG-PR_b for imaging of α5β\n1 by PET.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1011718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"1011719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"1011720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"破入, 正行"}],"nameIdentifiers":[{"nameIdentifier":"1011721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"1011722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011727","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"In vivo PET imaging of cancer α5β1-integrin using a pegylated peptide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo PET imaging of cancer α5β1-integrin using a pegylated peptide"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-01"},"publish_date":"2021-11-01","publish_status":"0","recid":"83860","relation_version_is_last":true,"title":["In vivo PET imaging of cancer α5β1-integrin using a pegylated peptide"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:58:39.963664+00:00"}