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Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin
https://repo.qst.go.jp/records/82977
https://repo.qst.go.jp/records/8297705ff37e6-9c59-4d4d-b90c-17bbac2a8a3e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-02 | |||||
| タイトル | ||||||
| タイトル | Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikoma, Yoko
× Ikoma, Yoko× Takuwa, Hiroyuki× Nishino, Asuka× Maeda, Jun× Kawamura, Kazunori× Obata, Takayuki× Ming-Rong, Zhang× Higuchi, Makoto× Suhara, Tetsuya× Yoko, Ikoma× Hiroyuki, Takuwa× Asuka, Nishino× Jun, Maeda× Kazunori, Kawamura× Takayuki, Obata× Zhang, Ming-Rong× Makoto, Higuchi× Tetsuya, Suhara |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positron emission tomography (PET) has been used to investigate changes in the concentration of endogenous neurotransmitters. Recently, this technique has been applied to the imaging of serotonin receptors using [18F]altanserin. In these measurements, a reduction in binding potential (BP) suggests an increase in endogenous serotonin levels caused by pharmacological or cognitive stimulations, and the sensitivity of BP reduction depends on the characteristics of [18F]altanserin. In this study, we evaluated an analytical method for estimating the changes in endogenous serotonin levels based on PET scans with [18F]altanserin at baseline and stimulated states and validated it using simulations and small animal PET studies. | |||||
| 書誌情報 |
Annals of nuclear medicine 巻 35, p. 955-965, 発行日 2021-06 |
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| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34101154 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-021-01633-4 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007%2Fs12149-021-01633-4 | |||||
