@article{oai:repo.qst.go.jp:00082977, author = {Ikoma, Yoko and Takuwa, Hiroyuki and Nishino, Asuka and Maeda, Jun and Kawamura, Kazunori and Obata, Takayuki and Ming-Rong, Zhang and Higuchi, Makoto and Suhara, Tetsuya and Yoko, Ikoma and Hiroyuki, Takuwa and Asuka, Nishino and Jun, Maeda and Kazunori, Kawamura and Takayuki, Obata and Zhang, Ming-Rong and Makoto, Higuchi and Tetsuya, Suhara}, journal = {Annals of nuclear medicine}, month = {Jun}, note = {Positron emission tomography (PET) has been used to investigate changes in the concentration of endogenous neurotransmitters. Recently, this technique has been applied to the imaging of serotonin receptors using [18F]altanserin. In these measurements, a reduction in binding potential (BP) suggests an increase in endogenous serotonin levels caused by pharmacological or cognitive stimulations, and the sensitivity of BP reduction depends on the characteristics of [18F]altanserin. In this study, we evaluated an analytical method for estimating the changes in endogenous serotonin levels based on PET scans with [18F]altanserin at baseline and stimulated states and validated it using simulations and small animal PET studies.}, pages = {955--965}, title = {Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin}, volume = {35}, year = {2021} }