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An Analysis of Vertebral Body Growth after Proton Beam Therapy for Pediatric Cancer.
https://repo.qst.go.jp/records/82765
https://repo.qst.go.jp/records/82765fc20549e-e4ec-4990-ba2f-80adb85d3831
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-23 | |||||
| タイトル | ||||||
| タイトル | An Analysis of Vertebral Body Growth after Proton Beam Therapy for Pediatric Cancer. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Baba, Keiichiro
× Baba, Keiichiro× Mizumoto, Masashi× Yoshiko, Oshiro× Shimizu, Shosei× Nakamura, Masatoshi× Yuichi, Hiroshima× Iizumi, Takashi× Saito , Takashi× Numajiri, Haruko× Kei, Nakai× Hitoshi, Ishikawa× Okumura, Toshiyuki× Maruo , Kazushi× Hideyuki, Sakurai× Yoshiko, Oshiro× Yuichi, Hiroshima× Kei, Nakai× Hitoshi, Ishikawa× Hideyuki, Sakurai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Impairment of bone growth after radiotherapy for pediatric bone cancer is a well-known adverse event.However, there is limited understanding of the relationship between bone growth and irradiation dose.In this study, we retrospectively analyzed bone growth impairment after proton beam therapy forpediatric cancer. A total of 353 vertebral bodies in 23 patients under 12 years old who received protonbeam therapy were evaluated. Compared to the non-irradiated vertebral body growth rate, the irradiatedvertebral body rate (%/year) was significantly lower: 77.2%, 57.6%, 40.8%, 26.4%, and 14.1% at 10, 20, 30, 40, and 50 Gy (RBE) irradiation, respectively. In multivariate analysis, radiation dose was theonly factor correlated with vertebral body growth. Age, gender, and vertebral body site were notsignificant factors. These results suggest that the growth rate of the vertebral body is dose-dependentand decreases even at a low irradiated dose. This is the first report to show that proton beam therapyhas the same growth inhibitory effect as photon radiotherapy within the irradiated field. | |||||
| 書誌情報 |
Cancers 巻 13, 号 2, p. 349, 発行日 2021-01 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-6694 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33477867 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cancers13020349 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6694/13/2/349 | |||||
