@article{oai:repo.qst.go.jp:00082765,
 author = {Baba, Keiichiro and Mizumoto, Masashi and Yoshiko, Oshiro and Shimizu, Shosei and Nakamura, Masatoshi and Yuichi, Hiroshima and Iizumi, Takashi and Saito , Takashi and Numajiri, Haruko and Kei, Nakai and Hitoshi, Ishikawa and Okumura, Toshiyuki and Maruo , Kazushi and Hideyuki, Sakurai and Yoshiko, Oshiro and Yuichi, Hiroshima and Kei, Nakai and Hitoshi, Ishikawa and Hideyuki, Sakurai},
 issue = {2},
 journal = {Cancers},
 month = {Jan},
 note = {Impairment of bone growth after radiotherapy for pediatric bone cancer is a well-known adverse event.However, there is limited understanding of the relationship between bone growth and irradiation dose.In this study, we retrospectively analyzed bone growth impairment after proton beam therapy forpediatric cancer. A total of 353 vertebral bodies in 23 patients under 12 years old who received protonbeam therapy were evaluated. Compared to the non-irradiated vertebral body growth rate, the irradiatedvertebral body rate (%/year) was significantly lower: 77.2%, 57.6%, 40.8%, 26.4%, and 14.1% at 10, 20, 30, 40, and 50 Gy (RBE) irradiation, respectively. In multivariate analysis, radiation dose was theonly factor correlated with vertebral body growth. Age, gender, and vertebral body site were notsignificant factors. These results suggest that the growth rate of the vertebral body is dose-dependentand decreases even at a low irradiated dose. This is the first report to show that proton beam therapyhas the same growth inhibitory effect as photon radiotherapy within the irradiated field.},
 title = {An Analysis of Vertebral Body Growth after Proton Beam Therapy for Pediatric Cancer.},
 volume = {13},
 year = {2021}
}