WEKO3
アイテム
{"_buckets": {"deposit": "201537ac-38f5-45c2-8622-694811db69d5"}, "_deposit": {"created_by": 1, "id": "82621", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "82621"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00082621", "sets": ["7"]}, "author_link": ["944232", "944231"], "item_10004_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "16", "bibliographicPageStart": "16", "bibliographic_titles": [{"bibliographic_title": "QST Takasaki Annual Report 2019 "}]}]}, "item_10004_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Positron emission tomography (PET) with amino acid analogs has great impacts on the treatment of cancer by diagnosis, staging, and monitoring. Among them, 3-18F-fluoro-α-methyl-L-tyrosine (18F-FAMT) has been routinely used for tumor diagnosis in Gunma University Hospital. The specific accumulation of 18F-FAMT in malignant tumors is exclusively promoted by L-type amino acid transporter 1 (LAT1), the expression of which is highly upregulated in many types of cancers. However, a major drawback of 18F-FAMT PET is the relatively high frequency of false-negative results because of its low tumor accumulation level. These clinical findings have prompted the further development of 18F-FAMT analogs with higher tumor accumulation and improved pharmacokinetics. In this study, we prepared 18F-FAMP regioisomers (2-, 3-, or 4-18F-FAMP) and stereoisomers (L- or D-form), and we comprehensively evaluated their potential as tumor-imaging agents. ", "subitem_description_type": "Abstract"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yasuhiro, Oshima"}], "nameIdentifiers": [{"nameIdentifier": "944231", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuhiro, Oshima", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "944232", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging"}]}, "item_type_id": "10004", "owner": "1", "path": ["7"], "permalink_uri": "https://repo.qst.go.jp/records/82621", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-04-05"}, "publish_date": "2021-04-05", "publish_status": "0", "recid": "82621", "relation": {}, "relation_version_is_last": true, "title": ["Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging"], "weko_shared_id": -1}
Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging
https://repo.qst.go.jp/records/82621
https://repo.qst.go.jp/records/82621552100b7-8fbb-4571-9cc6-07f88751398b
Item type | 一般雑誌記事 / Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-04-05 | |||||
タイトル | ||||||
タイトル | Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yasuhiro, Oshima
× Yasuhiro, Oshima× Yasuhiro, Oshima |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Positron emission tomography (PET) with amino acid analogs has great impacts on the treatment of cancer by diagnosis, staging, and monitoring. Among them, 3-18F-fluoro-α-methyl-L-tyrosine (18F-FAMT) has been routinely used for tumor diagnosis in Gunma University Hospital. The specific accumulation of 18F-FAMT in malignant tumors is exclusively promoted by L-type amino acid transporter 1 (LAT1), the expression of which is highly upregulated in many types of cancers. However, a major drawback of 18F-FAMT PET is the relatively high frequency of false-negative results because of its low tumor accumulation level. These clinical findings have prompted the further development of 18F-FAMT analogs with higher tumor accumulation and improved pharmacokinetics. In this study, we prepared 18F-FAMP regioisomers (2-, 3-, or 4-18F-FAMP) and stereoisomers (L- or D-form), and we comprehensively evaluated their potential as tumor-imaging agents. | |||||
書誌情報 |
QST Takasaki Annual Report 2019 p. 16-16, 発行日 2021-03 |