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Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice
https://repo.qst.go.jp/records/81621
https://repo.qst.go.jp/records/81621fe16409f-1147-425b-bca6-911f045b46a3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-07 | |||||
| タイトル | ||||||
| タイトル | Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Bing
× Wang, Bing× Tanaka, Kaoru× Katsube, Takanori× Maruyama, Kouichi× Ninomiya, Yasuharu× Vares, Guillaume× Liu, Cuihua× Hirakawa, Hirokazu× Murakami, Masahiro× Fardous, Zeenath× Nahida, Sultana× Fujita, Kazuko× Fujimori, Akira× Nakajima, Tetsuo× Nenoi, Mitsuru× Bing, Wang× Kaoru, Tanaka× Takanori, Katsube× Kouichi, Maruyama× Yasuharu, Ninomiya× Vares, Guillaume× Liu, Cuihua× Hirokazu, Hirakawa× Masahiro, Murakami× Fardous, Zeenath× Nahida, Sultana× Kazuko, Fujita× Akira, Fujimori× Tetsuo, Nakajima× Mitsuru, Nenoi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radioadaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses. Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR could significantly extenuate high-dose IR-induced detrimental effects such as decrease of hematopoietic stem cells and progenitor cells, acute radiation hematopoietic syndrome, genotoxicity and genomic instability. Meanwhile, it has been demonstrated that diet intervention has a great impact on health, and dietary restriction shows beneficial effects on numerous diseases in animal models. In this work, by using the mouse RAR model and mild dietary restriction (MDR), we confirmed that combination of RAR and MDR could more efficiently reduce radiogenotoxic damage without significant change of the RAR phenotype. These findings suggested that MDR may share some common pathways with RAR to activate mechanisms consequently resulting in suppression of genotoxicity. As MDR could also increase resistance to chemotherapy and radiotherapy in normal cells, we propose that combination of MDR, RAR, and other cancer treatments (i.e., chemotherapy and radiotherapy) represent a potential strategy to increase the treatment efficacy and prevent IR risk in humans. |
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| 書誌情報 |
Dose-Response 巻 19, 号 1, p. 1559325820982166, 発行日 2021-01 |
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| 出版者 | ||||||
| 出版者 | SAGE | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1559-3258 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1177/1559325820982166 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://journals.sagepub.com/doi/full/10.1177/1559325820982166 | |||||
