@article{oai:repo.qst.go.jp:00081621,
 author = {Wang, Bing and Tanaka, Kaoru and Katsube, Takanori and Maruyama, Kouichi and Ninomiya, Yasuharu and Vares, Guillaume and Liu, Cuihua and Hirakawa, Hirokazu and Murakami, Masahiro and Fardous, Zeenath and Nahida, Sultana and Fujita, Kazuko and Fujimori, Akira and Nakajima, Tetsuo and Nenoi, Mitsuru and Bing, Wang and Kaoru, Tanaka and Takanori, Katsube and Kouichi, Maruyama and Yasuharu, Ninomiya and Vares, Guillaume and Liu, Cuihua and Hirokazu, Hirakawa and Masahiro, Murakami and Fardous, Zeenath and Nahida, Sultana and Kazuko, Fujita and Akira, Fujimori and Tetsuo, Nakajima and Mitsuru, Nenoi},
 issue = {1},
 journal = {Dose-Response},
 month = {Jan},
 note = {Radioadaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses. Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR could significantly extenuate high-dose IR-induced detrimental effects such as decrease of hematopoietic stem cells and progenitor cells, acute radiation hematopoietic syndrome, genotoxicity and genomic instability. Meanwhile, it has been demonstrated that diet intervention has a great impact on health, and
dietary restriction shows beneficial effects on numerous diseases in animal models. In this work, by using the mouse RAR model and mild dietary restriction (MDR), we confirmed that combination of RAR and MDR could more efficiently reduce radiogenotoxic damage without significant change of the RAR phenotype. These findings suggested that MDR may share some common pathways with RAR to activate mechanisms consequently resulting in suppression of genotoxicity. As MDR could also increase resistance to chemotherapy and radiotherapy in normal cells, we propose that combination of MDR, RAR, and other cancer treatments (i.e., chemotherapy and radiotherapy) represent a potential strategy to increase the treatment efficacy and prevent IR risk in humans.},
 title = {Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice},
 volume = {19},
 year = {2021}
}