WEKO3
アイテム
{"_buckets": {"deposit": "ab7c4c44-728e-42ff-9574-b5164ee709da"}, "_deposit": {"created_by": 1, "id": "80607", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "80607"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00080607", "sets": ["1"]}, "author_link": ["1009388", "1009387", "1009382", "1009378", "1009384", "1009386", "1009381", "1009380", "1009379", "1009383", "1009385"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-09", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "144", "bibliographicVolumeNumber": "3", "bibliographic_titles": [{"bibliographic_title": "Communications Biology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The Creeper (Cp) chicken is characterized by chondrodystrophy in Cp/+ heterozygotes and embryonic lethality in Cp/Cp homozygotes. However, the genes underlying the phenotypes have not been fully known. Here, we show that a 25 kb deletion on chromosome 7, which contains the Indian hedgehog (IHH) and non-homologous end-joining factor 1 (NHEJ1) genes, is responsible for the Cp trait in Japanese bantam chickens. IHH is essential for chondrocyte maturation and is downregulated in the Cp/+ embryos and completely lost in the Cp/Cp embryos. This indicates that chondrodystrophy is caused by the loss of IHH and that chondrocyte maturation is delayed in Cp/+ heterozygotes. The Cp/Cp homozygotes exhibit impaired DNA double-strand break (DSB) repair due to the loss of NHEJ1, resulting in DSB accumulation in the vascular and nervous systems, which leads to apoptosis and early embryonic death.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s42003-020-0870-z", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s42003-020-0870-z", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2399-3642", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kinoshita, Keiji"}], "nameIdentifiers": [{"nameIdentifier": "1009378", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "1009379", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小池, 学"}], "nameIdentifiers": [{"nameIdentifier": "1009380", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Chizuko"}], "nameIdentifiers": [{"nameIdentifier": "1009381", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小池, 亜紀"}], "nameIdentifiers": [{"nameIdentifier": "1009382", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nunome, Mitsuo"}], "nameIdentifiers": [{"nameIdentifier": "1009383", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uemura, Takeo"}], "nameIdentifiers": [{"nameIdentifier": "1009384", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichiyanagi, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "1009385", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda, Yoichi"}], "nameIdentifiers": [{"nameIdentifier": "1009386", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Manabu, Koike", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1009387", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aki, Koike", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1009388", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/80607", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-09-25"}, "publish_date": "2020-09-25", "publish_status": "0", "recid": "80607", "relation": {}, "relation_version_is_last": true, "title": ["Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken"], "weko_shared_id": -1}
Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken
https://repo.qst.go.jp/records/80607
https://repo.qst.go.jp/records/8060740102a1b-25e1-4101-91ac-e45742dedc67
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-09-25 | |||||
タイトル | ||||||
タイトル | Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kinoshita, Keiji
× Kinoshita, Keiji× Suzuki, Takayuki× 小池, 学× Nishida, Chizuko× 小池, 亜紀× Nunome, Mitsuo× Uemura, Takeo× Ichiyanagi, Kenji× Matsuda, Yoichi× Manabu, Koike× Aki, Koike |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Creeper (Cp) chicken is characterized by chondrodystrophy in Cp/+ heterozygotes and embryonic lethality in Cp/Cp homozygotes. However, the genes underlying the phenotypes have not been fully known. Here, we show that a 25 kb deletion on chromosome 7, which contains the Indian hedgehog (IHH) and non-homologous end-joining factor 1 (NHEJ1) genes, is responsible for the Cp trait in Japanese bantam chickens. IHH is essential for chondrocyte maturation and is downregulated in the Cp/+ embryos and completely lost in the Cp/Cp embryos. This indicates that chondrodystrophy is caused by the loss of IHH and that chondrocyte maturation is delayed in Cp/+ heterozygotes. The Cp/Cp homozygotes exhibit impaired DNA double-strand break (DSB) repair due to the loss of NHEJ1, resulting in DSB accumulation in the vascular and nervous systems, which leads to apoptosis and early embryonic death. | |||||
書誌情報 |
Communications Biology 巻 3, p. 144, 発行日 2020-09 |
|||||
出版者 | ||||||
出版者 | Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2399-3642 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s42003-020-0870-z | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s42003-020-0870-z |