{"created":"2023-05-15T14:59:24.770575+00:00","id":80607,"links":{},"metadata":{"_buckets":{"deposit":"ab7c4c44-728e-42ff-9574-b5164ee709da"},"_deposit":{"created_by":1,"id":"80607","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80607"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080607","sets":["1"]},"author_link":["1009388","1009387","1009382","1009378","1009384","1009386","1009381","1009380","1009379","1009383","1009385"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"144","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Communications Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Creeper (Cp) chicken is characterized by chondrodystrophy in Cp/+ heterozygotes and embryonic lethality in Cp/Cp homozygotes. However, the genes underlying the phenotypes have not been fully known. Here, we show that a 25 kb deletion on chromosome 7, which contains the Indian hedgehog (IHH) and non-homologous end-joining factor 1 (NHEJ1) genes, is responsible for the Cp trait in Japanese bantam chickens. IHH is essential for chondrocyte maturation and is downregulated in the Cp/+ embryos and completely lost in the Cp/Cp embryos. This indicates that chondrodystrophy is caused by the loss of IHH and that chondrocyte maturation is delayed in Cp/+ heterozygotes. The Cp/Cp homozygotes exhibit impaired DNA double-strand break (DSB) repair due to the loss of NHEJ1, resulting in DSB accumulation in the vascular and nervous systems, which leads to apoptosis and early embryonic death.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s42003-020-0870-z","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s42003-020-0870-z","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2399-3642","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinoshita, Keiji"}],"nameIdentifiers":[{"nameIdentifier":"1009378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"1009379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 学"}],"nameIdentifiers":[{"nameIdentifier":"1009380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishida, Chizuko"}],"nameIdentifiers":[{"nameIdentifier":"1009381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 亜紀"}],"nameIdentifiers":[{"nameIdentifier":"1009382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nunome, Mitsuo"}],"nameIdentifiers":[{"nameIdentifier":"1009383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uemura, Takeo"}],"nameIdentifiers":[{"nameIdentifier":"1009384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichiyanagi, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"1009385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuda, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"1009386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manabu, Koike","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aki, Koike","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009388","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-25"},"publish_date":"2020-09-25","publish_status":"0","recid":"80607","relation_version_is_last":true,"title":["Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:07:56.371007+00:00"}